Equine Gastric Ulcer Syndrome (EGUS) — A Complete Guide
Equine Gastric Ulcer Syndrome (EGUS) is one of the most common conditions affecting horses in modern management systems. It refers to erosions or ulcerations of the stomach lining, and is now understood to encompass two distinct conditions with different causes, clinical presentations, and treatment approaches.
This guide, written by Dr. Louise Cosgrove of EEVS – Exclusively Equine Veterinary Services, explains everything horse owners need to know about gastric ulcers — from causes and signs to diagnosis, treatment, and prevention.
ESGUS vs EGGUS — Understanding the Difference
ESGUS — Squamous Ulcers
- Affects the upper, non-glandular squamous region
- No protective mucus layer — vulnerable to acid
- Caused by acid splashing during exercise
- Strongly linked to diet, exercise, and fasting
- Responds well to omeprazole (28-day course)
- Most common in racehorses and performance horses
- Graded 0–4 on gastroscopy
EGGUS — Glandular Ulcers
- Affects the lower glandular region
- Has a protective mucus layer — but can break down
- Associated with stress, NSAIDs, and Helicobacter-like organisms
- More common in warmbloods and sport horses
- Responds less reliably to omeprazole alone
- Often requires sucralfate added to treatment
- May require longer treatment course (56+ days)
The Ulcer Grading System
ESGUS — Squamous Gastric Ulcers
ESGUS squamous gastric ulcers are graded on a scale of 0 to 4 based on severity, as assessed during gastroscopy.
EGGUS — Glandular Gastric Ulcers
EGGUS uses its own severity classification, assessed during gastroscopy.
Prevalence of Ulcers in Horses
| Horse Type | Prevalence (ESGUS) | Key Risk Factors |
|---|---|---|
| Racehorses in training | ~93% | Intense exercise, high grain, fasting before work |
| Performance / Competition | 60–80% | Exercise, transport, competition stress, grain feeding |
| Endurance horses | ~70% | Long-distance exercise, electrolyte use, intermittent feeding |
| Pleasure horses | ~37% | Intermittent feeding, stabling, low forage access |
| Broodmares | ~67% | Late pregnancy, foaling stress, lactation |
| Foals | Up to 50% | Stress, illness, interrupted nursing |
Why Are Ulcers So Common?
The horse's stomach produces acid continuously — approximately 16 litres per day — regardless of whether food is present. In the wild, horses graze for 16–18 hours per day, keeping the stomach full of forage that physically buffers the acid and stimulates saliva production (which also buffers acid). Modern management practices disrupt this natural pattern in multiple ways: horses are stabled and fed twice daily, leaving the stomach empty for hours; large grain meals rapidly ferment to produce volatile fatty acids that damage the squamous mucosa; and intense exercise compresses the stomach, causing acid to splash onto the unprotected upper region.
What Does Gastroscopy Involve?
Gastroscopy is the only definitive way to diagnose equine gastric ulcers. The procedure involves fasting the horse for 12–18 hours (to empty the stomach), then passing a 3-metre flexible video endoscope through the nostril, down the oesophagus, and into the stomach. The horse is lightly sedated. The entire procedure takes approximately 20–30 minutes. Dr. Cosgrove can visualise the oesophagus, stomach (both squamous and glandular regions), and the pylorus, grade any ulcers found, and design a personalised treatment plan on the spot.